Researchers identify potential treatment target for genetic type of epilepsy

Researchers discovered a possible target for treating a hereditary form of epilepsy called CDKL5 deficient disorder (CDD). The study examined mice lacking the Cdkl5 gene and used phosphoproteomics to identify proteins targeted by the CDKL5 enzyme. The researchers found that Cav2.3, a calcium channel, is a target of CDKL5. Inhibiting Cav2.3 could potentially help with symptoms like seizures in both CDD and related conditions. These findings have implications for the development of targeted treatments for CDD and other types of epilepsy.